440841

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440841

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(1R,2S)-(+)-cis-1-Amino-2-indanol

99%

Synonym:(1R,2S)-(+)-cis-1-Amino-2-hydroxyindane
CAS Number:136030-00-7
Empirical Formula (Hill Notation):C9H11NO
Molecular Weight:149.19
Beilstein Registry Number:2803743
MDL number:MFCD00216656
PubChem Substance ID:24867628

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Diethyl malonimidate dihydrochloride

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Description

Packaging1, 5 g in glass btl
ApplicationThis cis-aminoindanol and its antipode have been used in the preparation of a series of potent HIV-1 protease inhibitory peptides.1,2,3,4,5,6,7,8 Also, they have served as chiral ligands in the catalytic asymmetric reduction of prochiral ketones with boranes.9,10

Properties

assay99%
optical activity[α]22/D +63°, c = 0.2 in chloroform
optical purityee: 99% (GLC)
mp118-121 °C(lit.)

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36
WGK Germany3

References

Cited Reference1. D'Aniello, F. et al. J. Org. Chem. 59, 3762, (1994)
 2. Dorsey, B.D. et al. Tetrahedron Lett. 34, 1851, (1993)
 3. Thaisrivongs, S. et al. J. Med. Chem. 36, 941, (1993) Abstract
 4. Thompson, W.J. et al. J. Med. Chem. 35, 1685, (1992) Abstract
 5. Young, S.D. et al. J. Med. Chem. 35, 1702, (1992) Abstract
 6. Tucker, T.J. et al. J. Med. Chem. 35, 2525, (1992) Abstract
 7. Askin, D. et al. J. Org. Chem. 57, 2771, (1992)
 8. Thompson, W.J. et al. Tetrahedron Lett. 33, 2957, (1992)
 9. Di Simone, B. et al. Tetrahedron Asymmetry 6, 301, (1995)
 10. Didier, E. et al. Tetrahedron 47, 4941, (1991)
referenceFT-IR 2 (2), 2201:A / Structure Index 1, 235:B:4